Research Interest

1)The establishment of induced pluripotent stem cell bank of patient and new drug screen ;2) Differentiation of hPSC into specific neurons;3)Study on cell replacement therapy for neurological dieases;4)Pre-clinical assessment and clinical assessment of stem cell transplantation;5)Assessment of the effect of rehabilitation strategy on stem cells transplantation.

Education

Doctor--Neurology-- Tongji Medical College, Huazhong University of Science and Technology--2005

Master--Neurology-- Medical College, Wu Han University--2002

Bachelor--Medicine--Hubei Medical College--1999

Oversea Study and Visit

Visiting Scholar,Waisman Center, UW ,United States of America,9/2013-12/2014

Joint Research,Waisman Center, UW ,United States of America,2/2011-6/2013

Academic Memberships

Honours and Awards

The top ten young teachers,Huazhong University of Science and Technology,2014

Prize for Outstanding Contributor,Tongji Hospital,2015

the backbone of young medical personnel,Wuhan City,2016

Honours and Awards

[1] 1. Mao Z, Zhang S, Chen H.*. Stem cell therapy for amyotrophic lateral sclerosis.Cell Regen (Lond). 2015, 19;4:11. 1186/s13619-015-0026-7. eCollection 2015. 2. Chen H, Qian K, Du ZW, Cao JY, Petersen A, Liu H, Blackbourn L, Zhang SC*. Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons. Cell Stem Cell. 2014, 14(6):796-809. 3. Chen H*, Qian K, Chen W, Hu BY, Lisle W. B, Du Z, Ma L, Liu H, Knobel KM, Ayala M, Zhang SC*. Replacement of adult mouse astrocytes by human stem cells: a chimeric model. Journal of Clinical Investigation. 2015, 125(3):1-10. 4. Du ZW, Chen H, Liu H, Lu J, Qian K, Huang CL, Zhong X, Fan F, Zhang SC.Nat Commun. 2015, 25; 6:6626. 5. Liu H, Lu J, Chen H , Du ZW, Li XJ, Zhang SC. Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Sci Rep. 2015; 5: 12189. 6. Qian K, Huang Cindy, Chen H, Du ZW, Zhang SC*. A Simple and Efficient System for Regulating Gene Expression In Human Pluripotent Stem Cells and Derivatives. Stem Cell, 2014; 32(5):1230-8. 7. Lu J, Liu H, Huang CT, Chen H, Du Z, Liu Y, Sherafat MA, Zhang SC. Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep. 2013; 3(5):1580-91. 8. Xi J, Liu Y, Liu H, Chen H, Emborg ME, Zhang SC*. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells. 2012; 30(8):1655-63. 9. Zhang Y , Liu N, Tang YX, Yang E, Dong S, Huang M, Chen H, Tang ZP，Efficient generation of neural stem cell-like cells from rat adipose derived stem cells after lentiviral transduction with Green Fluorescent Protein，Mol Neurobio, 2014, 50(2):647-54. 10. Hu L, Li H, Huang CL, Chen H, Zhu G, Qian K. Regulation of myeloid ecotropic viral integration site 1 and its expression in normal and abnormal endometrium. Fertility and sterility, 2014, 102(3), 856-863. 11. Chen H, Qian K, Tang ZP, Xing B, Chen H, Liu N, Huang X, Zhang S*. Bioinformatics and microarray analysis of microRNA expression profiles of murine embryonic stem cells, neural stem cells induced from ESCs and isolated from E8.5 mouse neural tube. Neurol Res. 2010，32 (6), 603-13. 12. Han X, Huang X, Wang Y, Chen H. A study of astrocyte activation in the periinfarct region after cerebral ischemia with electroacupuncture. Brain Injury, 2010, 24(5), 773-779. 13. Guo F, Han X, Zhang J, Zhao X, Lou J, Chen H, Huang X. Repetitive Transcranial Magnetic Stimulation Promotes Neural Stem Cell Proliferation via the Regulation of MiR-25 in a Rat Model of Focal Cerebral Ischemia. PloS one, 2014, 9(10), e109267. (IF: 3.534)，SCI网络版 14. Qian K, Hu L, Chen H, Li H, Liu N, Li Y, Ai J, Zhu G, Tang Z, Zhang H. Hsa-miR-222 is involved in differentiation of endometrial stromal cells in vitro. Endocrinology. 2009; 150(10):4734-43. 15. Chen H, Qian K, Hu J, Liu D, Lu W, Yang Y, Wang D, Yan H, Zhang S*, Zhu G. The derivation of two additional human embryonic stem cell lines from day 3 embryos with low morphological scores. Hum Reprod. 2005, 20(8), 2201-6. 16. Qian K, Chen H(共一作者), Wei Y, Hu J, Zhu G. Differentiation of endometrial stromal cells in vitro: down-regulation of suppression of the cell cycle inhibitor p57 by HOXA10?. Molecular human reproduction, 2005, 11(4), 245-251.