Research Interest

The work in our lab is focused on the structure-based protein engineering. We use methods, such as X-ray crystallography, NMR and homology modeling, to determine or predict the protein structures. Based on the structural information, we perform engineering work to alter the functions of target proteins with the intend to meet the specific needs in various applications in academia and industry.

Education

Doctor--Biochemistry--Univ. of Notre Dame, USA--2006

Oversea Study and Visit

Post Doctoral,University of Illinois at Urbana-Champaign,USA,2006-2009

Academic Memberships

Honours and Awards

Honours and Awards

[1] Zhang, H., Chen, J., Wang, H., Xie, Y., Ju, J., Yan, Y., & Zhang, H*. ,Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis.,FEBS Lett. 2013 Jun 5;587(11):1675-80. ,2013,

[2] Zheng, L., Zhou, X., Zhang, H., Ji, X., Li, L., Huang, L., . . . Zhang, H*., Structural and functional analysis of validoxylamine A 7//-phosphate synthase ValL involved in validamycin A biosynthesis. ,PLoS One, 7(2), e32033.,2012,

[3] Cicchillo, R. M., Zhang, H., Blodgett, J. A., Whitteck, J. T., Li, G., Nair, S. K., . . . Metcalf, W. W.,An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.,Nature,2009,

[4] Rubin-Pitel, S. B., Zhang, H., Vu, T., Brunzelle, J. S., Zhao, H., & Nair, S. K. ,Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa. ,Chem Biol, 15(10), 1079-1090.,2008,