Name: Wang Hui

Professor in School of Basic Medicine

Phone: 86-27-83692609


Academic Areas: Department of Medical Genetics

Research Interest

Bone marrow stem cells attenuate acute inflammatory response and its underlying mechanism


Doctor--Medical Immunology --Tongji Medical College, Wuhan, China--2007

Master--Medical Genetics--Tongji Medical College, Wuhan, China--2004

Bachelor--Medical Genetics--Tongji Medical College, Wuhan, China--1999

Oversea Study and Visit

Post Doctoral,University of Pittsburgh Medical Center,USA,2011-04-30-2012-04-30

Academic Memberships

Honours and Awards

Honours and Awards

[1] Wang Hui (王慧), Zhang Jinxiang, Wu Heshui, Li Zhuoya, Zheng Qichang,Bone marrow and non-bone marrow TLR4 regulates hepatic ischemia/ reperfusion injury,Biochemical and Biophysical Research ,2009,Hepatic ischemia–reperfusion injury (IRI) is a highly coordinated process often observed during liver transplantation, liver surgery, and hemorrhagic shock. Signaling through toll-like receptor 4 (TLR4),which is widely expressed on all kinds of liver cells, appears critical in the pathogenesis of IRI. Although the role of TLR4 expressed on non-parenchymal cells (NPCs) of the liver, including Kupffer cells and neutrophils, in IRI has been widely studied, TLR4 signaling on liver sinusoidal endothelial cells (LSECs) or hepatocytes in the process of IRI, and their coordination with bone marrow derived TLR4 in the late reperfusion stage, is largely unknown. We produced TLR4 chimeric mice that received hepatic IRI, and examined the degree of liver injury and the underlying mechanisms of injury. Results indicated that mutation of TLR4 on bone-marrow or non-bone marrow derived cells reduced hepatic IRI in the late reperfusion stage via cytokine release and neutrophil infiltration, while non-bone marrow derived TLR4 regulated the expression of ICAM-1 on hepatocytes and LSECs, exacerbating their injury. In conclusion,both TLR4 on bone marrow derived and non-bone marrow derived cells were necessary in the process of hepatic IRI.