Name: Guo Huan

Professor in School of Public Health

Phone: 86-27-83657914


Academic Areas: Department of Occupational and Environmental Health

Research Interest

1.Molecular epidemiology studies of genetic susceptibility and gene-environment interactions in lung carcinogenesis. 2.Biomarkers for early screening and exposure assessment of high risk populations of lung cancer. 3.Studies on the biological effects of occupational and environmental polycyclic aromatic hydrocarbons (PAHs) exposure and genetic damage of coke oven workers with the techniques of molecular and cellular biology, toxicology, and epidemiology.


Doctor--Occupational and Environmental Health--Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China--2005

Bachelor--Preventive Medicine--Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China--2000

Oversea Study and Visit

Visiting Scholar,Yale School of Public Health,USA,2012-11-12-2013-11-12

Academic Memberships

Honours and Awards

100 National Excellent Doctoral Dissertations in China,Ministry of Education of China,2012

New Century Excellent Talents in University of Ministry of Education of China,Ministry of Education of China,2012

Honours and Awards

[1] Guo H, Deng Q, Wu C, Hu L, Wei S, Xu P, Kuang D, Liu L, Hu Z, Miao X, Dr. Shen H, Lin D, Wu T.,Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.,Cancer Res.,2011,

[2] Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F, Jin G, Wang F, Deng Q, Tu Y, Feng M, Lu D, Shen H, Wu T. ,Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival.,J Clin Oncol. ,2010,

[3] Yang M, Guo H*, Wu C, He Y, Yu D, Zhou L, Wang F, Xu J, Tan W, Wang G, Shen B, Yuan J, Wu T, Lin D. ,Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. ,Hum Mutat.,2009,

[4] Deng Q, Guo H, Dai J, Yang L, Wu C, Wang Q, Hu Z, Yang M, Liu L, Yu D, Hu D, Hong X, Qiu F, Yang H, Wang T, Tan W, Chu M, Feng J, Teng K, Gong J, Sun C, Hu X, Zhang K, Lu J, Lin D, Shen H, Wu T. ,Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.,Carcinogenesis. ,2013,

[5] Xu P, Liu L, Wang J, Zhang K, Hong X, Deng Q, Xiang J, Zhang X, He M, Wu T, Guo H*.,Genetic variation in BCL2 3’-UTR was associated with lung cancer risk and prognosis in male Chinese population. ,PLoS One. ,2013,

[6] Xin L, Wang J, Guo S, Wu Y, Li X, Deng H, Kuang D, Xiao W, Wu T, Guo H*,Organic extracts of coke oven emissions can induce genetic damage in metabolically competent HepG2 cells.,Environ Toxicol Phar.,2014,

[7] Deng Q, Dai X, Guo H, Huang S, Kuang D, Feng J, Wang T, Zhang W, Huang K, Hu D, Deng H, Zhang X, Wu T. ,Polycyclic Aromatic Hydrocarbons-Associated MicroRNAs and Their Interactions with the Environment: Influences on Oxidative DNA Damage and Lipid Peroxidation in Coke Oven Workers., Environ Sci Technol.,2014,

[8] Guo H, Jin Y, Cheng Y, Leaderer B, Lin S, Holford TR, Qiu J, Zhang Y, Shi K, Yong Zhu Y, Niu J, Bassig BA, Li Y, Hu X, Chen Q, Zheng T. ,Prenatal exposure to organochlorine pesticides and infant birth weight in China.,Chemosphere. ,2014,

[9] Kuang D, Zhang W, Deng Q, Zhang X, Huang K, Guan L, Hu D, Wu T, Guo H*,Dose-response relationships of polycyclic aromatic hydrocarbons exposure and oxidative damage to DNA and lipid in coke oven workers. ,Environ Sci Technol.,2013,

[10] Guo H*, Huang K, Zhang X, Zhang W, Guan L, Kuang D, Deng Q, Deng H, Zhang X, He M, Christiani D, Wu T,Women are more susceptible than men to oxidative stress and chromosome damage caused by polycyclic aromatic hydrocarbons exposure. ,Environ Mol Mutagen.,2014,

[11] He M, Wu C, Xu J, Guo H*, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, Feng Y, Zhang H, Min X, Yang X, Zhu J, Zhai K, Chang J, Qin X, Tan W, Hu Y, Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim ST, Zhang S, Zhang ,A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.,Gut. ,2014,