Research Interest

We study intestinal mucosa immune signal transduction regulation mechanism induced by probiotic LPS and peptidoglycan recognized on intestinal epithelial cell. The effect specialty of LPS and peptidoglycan maintaining intestinal epithelial innate immune will be determined, the theory of intestinal mucosa first line defense may be clarified. Under the continued LPS and peptidoglycan stimulation，the regulation pattern of TLR and CD14 related signal transduction factor IRAK1和IRAK4 et al will be analyzied, TLR expression dose and time depedency stimulated by the different probiotic strain derived LPS will be observed. By use of non-cytotoxic dosage LPS，we will treat germ free colitis mouse, detect IL-1β,TNF-α,IL6,IL8,et al expression level change. TLRmRNA and protein distribution in the intestinal epithelial cell will be determined in the cell line, the exprimental mouse, ulcer colitis patient and normal human sample. It will be helpful to complete ulcer colitis pathogenesis understanding. The typical probiotic biological activity element LPS will be isolated, the most immune activity LPS will be identify and selected, to set a foundation for further purify production. This research work will provide new prevent and treatment strategy method. If this reseach work can be supported , it have a great social and economic value.

Education

Doctor--Gastroenterology--Union Hospital, Wuhan,China--1997

Master--Internal Medicine--Tongji Hospital,Wuhan,China--1993

Bachelor--Internal Medicine--Tongji Medical University,Wuhan,China--1990

Oversea Study and Visit

Post Doctoral,Medical center, University of Chicago,USA,1999-07-01-2002-12-30

Academic Memberships

Honours and Awards

Honours and Awards

[1] Hongyu Ren , et al., Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mucosa colonic epithelial cells. ,Gastroenterology 2003;124(5):1395-1407,2014,