Research Interest

Our work focuses on understanding the cellular and molecular mechanisms underlying substrate transport in the kidney tubules. SGK3 is a serine-threonine kinases, which regulates a variety of cellular processes, abnormalities in these signaling pathways can result in decreased bone density and severe phosphaturia.

Education

Doctor--Clinical Medicine--Tuebingen University, Germany--2004

Master--Nephrology--Tongji Medical University,China--1998

Bachelor--Clinical medicine--Shangdong Medical University,Shandong--1993

Oversea Study and Visit

Oversea Training,Tuebingen Universiy,Germany,2001-11-12-2004-08-31

Post Doctoral,University of California, San Francisco,USA,2008-04-07-2010-04-30

Academic Memberships

Honours and Awards

Honours and Awards

[1] Yao LJ (姚丽君), McCormick JA, Wang J, Yang KY, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D,Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double null mice.,Mol Endocrinol,2011,

[2] Zhao H, Yao X, Wang TX, Jin WM, Ji QQ, Yang X, Duan QH, Yao LJ*,PKCα regulates vasopressin-induced aquaporin-2 trafficking in mouse kidney collecting duct cells in vitro via altering microtubule assembly,Acta Pharmacol Sin.,2012,

[3] Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ　(姚丽君), Shokat KM, Ashrafi K, Pearce D,mTOR complex-2 activates ENaC by phosphorylating SGK1.,J Am Soc Nephrol,2010,

[4] Yao L(姚丽君), Huang DY, Pfaff IL, Nie X, Leitges M, Vallon V ,Evidence for a role of protein kinase C alpha in urine concentration.,Am. J. Physiol Renal Physiol. ,2004,

[5] Li-Jun Yao(姚丽君), Michael Leitges, and Volker Vallon,Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl –induced metabolic acidosis.,Kidney Blood Press Res.,2006,

[6] Li-Jun Yao(姚丽君), Jian-Qing Wang, Hong Zhao, Jian-She Liu, An-Guo Deng,Effect of telmisartan on expression of protein kinase C-alpha in kidneys of diabetic mice,Acta Pharmacologica Sinca,2007,