Research Interest

tumor biology, cancer cell proliferation and metastasis

Education

Doctor--Oncology--Chinese Academy of Medical Science,Beijing,China--1999

Master--Pharmaology--Henan Medical Unioversity,Zhengzhou,China--1988

Bachelor--Medical Science--Henan Medical Unioversity,Zhengzhou,China--1984

Oversea Study and Visit

Joint Research,Georgetown University,USA,2004-04-01-2005-11-30

Post Doctoral,Georgetown University,USA,2002-10-01-2004-03-31

Post Doctoral,Albert Einstein College of Medicine,USA,1999-04-15-2002-08-31

Visiting Scholar,National Cancer Center of Japan,Japan,1994-09-30-1995-10-01

Joint Research,Thomas Jefferson University,USA,2005-12-01-2013-06-30

Academic Memberships

Honours and Awards

Margaret Q. Landenberger Foundation,Research grant, Principle Investigator,2008

DoD New Investigator Award,Medical Research-Prostate Cancer, Principle Investigator ,2011

General Project,National Science Foundation of China, Principle Investigator,2010

General Project,National Science Foundation of China, Principle Investigator,2011

NSFC-NIH Joint Project,National Science Foundation of China, Principle Investigator,2012

Honours and Awards

[1] Wu K*, Li Z, Cai S, Tian L, Chen K, Wang J, Hu J, Sun Y, Li X, Ertel A, Pestell R,EYA1 phsophatase function is essential to drive breast cancer cellular proliferation through cyclin D1,Cancer Research,2013,corresponding author

[2] Chen K, Wu K*, Gormley M, Ertel A, Wang J, Zhang W, Zhou J, Disante G, Li Z, Rui H, Quong AA, McMahon SB, Deng H, Lisanti MP, Wang C, Pestell RG,Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer,Oncotarget,2013,corresponding author

[3] Wu K* Chen K, Wang C, Jiao X, Wang L, Zhou J, Wang J, Li Z, Addya S, Sorensen PH, Lisanti MP, Quong A, Ertel A, Pestell RG*,Cell Fate Factor DACH1 Represses YB-1-Mediated Oncogenic Transcription and Translation. ,Cancer Research,2014,corresponding author

[4] Zhu H, Wu K, Yan W, Hu L, Yuan J, Dong Y, Li Y, Jing K, Yang Y, Guo M., Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative response in human hepatocellular carcinoma,Hepatology,2014,

[5] Chen K, Wu K*, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Wang C, McMahon SB, Pestell RG.,Dachshund binds p53 to block the growth of lund adnocarcinoma cells,Cancer Research,,2014,

[6] Wu K*, Jiao X, Li Z, Katiyar S, Casimiro MC, Yang W, Zhang Q, Willmarth NE, Chepelev I, Crosariol M, Wei Z, Hu J, Zhao K, Pestell RG*,The cell-fate determination factor dachshund reprograms breast cancer stem cell function. ,J Biol Chem,2011,

[7] Popov VM, Wu K*, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG. ,The Dachshund gene in development and hormone-responsive tumorigenesis,Trends Endocrinol Metab,2010,

[8] Zhou J, Wang C, Wang Z, Dampier W, Wu K, Casimiro MC, Chepelev I, Popov VM, Quong A, Tozeren A, Zhao K, Lisanti MP, Pestell RG., Attenuation of Forkhead signaling by the retinal determination factor DACH1.,Proc Natl Acad Sci U S A,2010,

[9] Wu K*, Katiyar S, Witkiewicz A, Li A, McCue P, Song LN, Tian L, Jin M, Pestell RG. ,The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth. ,Cancer Res,2009,

[10] Wu K, Katiyar S, Li A, Liu M, Popov VM, Ju X, Jiao X, Casola A, Pestell RG.,Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of Interleukin-8. , Proc Natl Acad Sci U S A,2008,

[11] Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, Lisanti M, Cvekl A, Birrer M, Pestell RG,The cell fate determination factor DACH1 inhibits c-jun induced contact-independent growth.,Mol. Biol. Cell,2007,

[12] Wu K, Li A, Rao M, Liu M, Dailey V, Yang Y, Di Vizio D, Wang C, Lisanti MP, Sauter G, Russell RG, Cvekl A, Pestell RG.,DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth,Mol. Cell. Biol.,2006,